Epithalon

About Epithalon

Epithalon (Epitalon) is a synthetic tetrapeptide made up of four amino acids: alanine, glutamic acid, aspartic acid, and glycine. Professor Vladimir Khavinson developed it at the St. Petersburg Institute of Bioregulation and Gerontology, and it's caught the attention of researchers for its potential role in how our cells age. Here's what makes it interesting — the peptide works by activating telomerase, an enzyme that keeps our chromosome telomeres at proper length. Research has shown that Epithalon can actually extend telomeres in cultured human cells and boost telomerase activity by up to 33%. That's quite significant. But there's more to it. Scientists have also looked into how it affects our circadian rhythms by working with the pineal gland and melatonin production. It's being used in various research areas — cellular ageing studies, longevity research, and investigations into our body clocks. Lab studies have produced some promising results. We're seeing extended cellular lifespan and improved DNA repair mechanisms in controlled conditions. Our pharmaceutical-grade Epithalon comes as a lyophilised powder with over 98% purity. We verify this through HPLC analysis and store it under optimal conditions to keep it stable. It's strictly for in vitro research applications only.

Research Applications

• Investigated for its association with telomerase enzymatic activity in cultured human cells
• Studied for effects on telomere length dynamics in fibroblast and somatic cell lines
• Researched for circadian rhythm and melatonin signalling pathways in pineal models
• Investigated in cellular senescence and ageing-marker gene expression studies
• Explored in oxidative stress and antioxidant defence research using rodent tissue assays
• Studied for cortical neuron differentiation and neuroprotective signalling in vitro

Research Mechanism — Epithalon

A simplified summary of what Epithalon is studied for in research models. For laboratory in-vitro use only.

1. 1

   Molecular target

   Epithalon has been investigated for effects on the telomerase reverse transcriptase (TERT) gene and pineal-axis signalling. Studies have characterised its interaction with chromatin and telomere-maintenance machinery.

   • TERT (telomerase reverse transcriptase) gene expression
   • Pineal-associated indoleamine pathway components
   • Chromatin binding in cultured fibroblast nuclei
2. 2

   Investigated pathways

   Preclinical studies have explored downstream effects on telomere length, melatonin synthesis, and circadian regulators. Associated signalling involves pineal AANAT and HIOMT enzymes.

   • Telomere elongation in human somatic cell cultures
   • AANAT and HIOMT enzyme activity in pineal tissue
   • Circadian clock gene (Per, Bmal1) expression
3. 3

   Preclinical research applications

   Preclinical studies have investigated Epithalon in rodent ageing cohorts and human fibroblast culture systems. Not approved for human use.

   • Murine lifespan and ageing-marker studies
   • Human fetal fibroblast (HFF) telomerase assays
   • Pineal-gland indoleamine biosynthesis models

For research use only. Epithalon is not approved as a medicine in the UK and is not intended for human or veterinary administration. See the compliance page for full terms.