TB-500

About TB-500

TB-500 (Thymosin Beta-4 Fragment 17-23) is a synthetic acetylated heptapeptide that mimics the active region of the naturally occurring Thymosin Beta-4 protein. This research compound works through actin sequestration mechanisms, binding to G-actin monomers and preventing polymerisation into F-actin filaments. Preclinical studies have shown TB-500's significant involvement in cellular migration, angiogenesis, and wound healing pathways. Research published in the Journal of Cellular Physiology demonstrates its potential role in promoting endothelial cell migration and vascular development. Other studies have looked at its effects on keratinocyte migration and dermal repair mechanisms. What makes TB-500 particularly valuable for in vitro research is its unique ability to cross cell membranes without needing carriers. Our TB-500 comes as a sterile lyophilised powder with >98% purity via HPLC analysis, molecular weight 889.9 Da, and CAS number 77591-33-4. Each vial contains precisely measured quantities for consistent experimental protocols. It's suitable for tissue engineering research, cell culture studies, and regenerative biology investigations. For laboratory research use only.

Research Applications

• Studied for its role in G-actin binding and actin cytoskeleton remodelling in cultured cell lines.
• Investigated in preclinical wound-healing models for its association with keratinocyte and endothelial cell migration.
• Researched for involvement in angiogenesis pathways and capillary tube formation assays in vitro.
• Examined for its role in muscle and cardiac tissue repair signalling in rodent injury models.

Research Mechanism — TB-500

A simplified summary of what TB-500 is studied for in research models. For laboratory in-vitro use only.

1. 1

   Molecular target

   A research peptide investigated for its binding to G-actin monomers and modulation of cytoskeletal dynamics in laboratory models. Its actin-sequestering motif is studied for downstream effects on cell motility complexes.

   • G-actin monomer (actin-sequestering motif)
   • Integrin-linked kinase (ILK) signalling
   • Laminin-5 and fibronectin matrix interactions
2. 2

   Investigated pathways

   Preclinical studies have explored downstream effects on actin polymerisation dynamics, angiogenic signalling, and cellular migration responses in vitro.

   • Actin polymerisation and cytoskeletal remodelling
   • VEGF-driven endothelial migration assays
   • AKT and ILK survival-signalling cascades
3. 3

   Preclinical research applications

   Used as a research tool in laboratory models exploring cell-migration biology, vascular research, and connective-tissue science. Not approved for human use.

   • Cardiac and skeletal myocyte migration models
   • Corneal and epithelial wound-healing assays
   • Tendon and ligament fibroblast studies

For research use only. TB-500 is not approved as a medicine in the UK and is not intended for human or veterinary administration. See the compliance page for full terms.