Ipamorelin

About Ipamorelin

Ipamorelin is a synthetic pentapeptide (APDARP) that works as a highly selective growth hormone secretagogue receptor (GHS-R1a) agonist. This research peptide shows remarkable specificity in stimulating growth hormone release whilst having minimal impact on cortisol, prolactin, or ACTH levels—setting it apart from other growth hormone releasing peptides. It works by binding to ghrelin receptors in the pituitary gland, triggering natural GH secretion in a pulsatile pattern that mirrors the body's own physiological rhythms. Preclinical studies have looked at Ipamorelin's potential applications in growth hormone deficiency research, metabolic studies, and investigations into age-related decline. Research shows it keeps working effectively without desensitisation over long periods, which makes it valuable for extended studies. Premio Peptides supplies pharmaceutical-grade Ipamorelin as lyophilised powder with >98% purity, verified through HPLC analysis. Each vial contains precisely measured quantities for accurate research protocols. When stored at -20°C, the peptide remains stable for extended periods. You'll need bacteriostatic water for reconstitution to achieve optimal stability. Strictly for in vitro laboratory research and not intended for human consumption or therapeutic use.

Research Applications

• Studied for its role as a selective GHS-R1a agonist with minimal cross-reactivity at cortisol or prolactin pathways.
• Investigated in preclinical rodent models for association with pulsatile GH release profiles.
• Researched for its role in slow-wave sleep architecture and somatotroph signalling in animal studies.
• Examined for involvement in nitrogen retention and protein synthesis pathways in cell culture studies.

Research Mechanism — Ipamorelin

A simplified summary of what Ipamorelin is studied for in research models. For laboratory in-vitro use only.

1. 1

   Molecular target

   A selective growth hormone secretagogue investigated for its binding to the ghrelin receptor on pituitary somatotrophs and hypothalamic neurons in research models.

   • Growth hormone secretagogue receptor (GHSR-1a)
   • Pituitary somatotroph cell membrane
   • Hypothalamic arcuate nucleus neurons
2. 2

   Investigated pathways

   Preclinical studies have explored downstream effects on phospholipase C signalling, intracellular calcium mobilisation, and pulsatile GH-release patterns in cultured cells.

   • Gαq–PLC–IP3 calcium-mobilisation cascade
   • Pulsatile GH secretion assays
   • Selective GH release without ACTH or prolactin
3. 3

   Preclinical research applications

   Used as a research tool in laboratory models exploring somatotroph endocrinology, ghrelin-receptor pharmacology, and growth-hormone axis research. Not approved for human use.

   • GHSR-1a receptor selectivity assays
   • Somatotroph cell-line GH secretion models
   • Rodent GH-pulsatility research studies

For research use only. Ipamorelin is not approved as a medicine in the UK and is not intended for human or veterinary administration. See the compliance page for full terms.