Follistatin 344 research peptide
Growth & Muscle

Follistatin 344

Recombinant 344-residue follistatin isoform investigated for myostatin/activin binding and muscle research.

Purity

99%+

CAS Number

80449-31-6

Status

Made to Order

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£199.99

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Research verification required. All orders are reviewed before dispatch. You will receive an email confirmation and a WhatsApp or phone call within 60 minutes to verify your research purpose.

Third-Party CoA Included Free Delivery Over £75 Research Use Only

About Follistatin 344

Follistatin 344 (FST-344) is the longer 344-residue isoform of human follistatin, a secreted glycoprotein that binds and neutralises members of the TGF-β superfamily, most notably myostatin (GDF-8) and activin A. Researchers study FST-344 in skeletal-muscle models for its role in muscle-mass regulation, fibrosis pathways and reproductive endocrinology. Supplied lyophilised for in vitro laboratory research only.

Research Applications

Research Mechanism — Follistatin 344

A simplified summary of what Follistatin 344 is studied for in research models. For laboratory in-vitro use only.

Sequence:344-amino-acid glycoprotein (full-length isoform of human FST gene; secreted form lacking the C-terminal acidic tail of FST-315)

Origin: Follistatin 344 (FST-344) is a recombinant single-chain glycoprotein isoform encoded by the FST gene, characterised as a high-affinity binding antagonist of TGF-β superfamily ligands.

  1. Molecular target

    Follistatin 344 has been studied for its high-affinity binding to myostatin (GDF-8) and activin A within the TGF-β superfamily. Investigations have characterised its sequestration of these ligands away from their type II receptors.

    • Myostatin (GDF-8) sequestration from ActRIIB
    • Activin A binding and ActRIIA blockade
    • GDF-11 cross-reactive binding in vitro

  2. Investigated pathways

    Preclinical studies have explored downstream Smad2/3 signalling suppression following ligand neutralisation. Associated signalling involves myogenic differentiation programmes.

    • Reduced Smad2/3 phosphorylation in myocytes
    • Upregulation of MyoD and myogenin transcription
    • Attenuated atrogin-1/MuRF1 atrophy gene expression

  3. Preclinical research applications

    Preclinical studies have investigated Follistatin 344 in murine skeletal-muscle models and viral-vector overexpression paradigms. Not approved for human use.

    • Mdx mouse muscular-dystrophy research models
    • AAV-FST344 gene-delivery skeletal muscle studies
    • C2C12 myoblast differentiation assays

For research use only. Follistatin 344 is not approved as a medicine in the UK and is not intended for human or veterinary administration. See the compliance page for full terms.

Technical Specifications

Compound NameFollistatin 344
CategoryGrowth & Muscle
CAS Number80449-31-6
Molecular Weight~37.8 kDa (FST-344 isoform)
Molecular FormulaRecombinant protein — empirical formula not standardly reported
SequenceFST-344: 344-residue secreted glycoprotein (mature isoform begins GNCWLRQAKNGRCQVLYKTELSKEECCSTGRL...). Full-length sequence per UniProt P19883.
Purity≥99%+ (HPLC)
FormLyophilised powder
StorageStore lyophilised at -20°C. Protect from light. Reconstituted: aliquot and store at -80°C. Use within 30 days of reconstitution.
ReconstitutionReconstitute in sterile water or PBS. Typical stock concentration: 0.1-0.5 mg/mL; carrier protein (e.g. 0.1% BSA) recommended for dilute working solutions.

Certificate of Analysis

Every order of Follistatin 344 includes a batch-specific CoA with HPLC chromatogram, mass spectrometry data, and laboratory accreditation details.

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Follistatin 344 — Frequently Asked Questions

What is Follistatin 344?

Follistatin 344 (FST-344) is the 344-residue isoform of human follistatin, a secreted glycoprotein researched for binding and neutralising myostatin and activin A in skeletal-muscle and endocrine signalling studies.

What purity is your Follistatin 344?

99%+, confirmed by independent third-party HPLC analysis. Batch-specific CoA included.

Is Follistatin 344 approved for human use?

No. Supplied for in vitro laboratory research only. Not a licensed medicine.

📊Certificates of Analysis🔬Quality & Testing📋Research Guidelines⚖️UK Compliance

Follistatin 344 is supplied by Premio Peptides (BELL RED LIMITED) exclusively for in vitro laboratory research. It is not a licensed medicine, is not approved for human or veterinary use, and must not be administered to any living organism outside a formally approved research protocol. Purchasers assume full responsibility for compliance with applicable regulations.

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