Kisspeptin-10

About Kisspeptin-10

Kisspeptin-10 is a synthetic decapeptide that represents the biologically active C-terminal fragment of kisspeptin-54, which comes from the KISS1 gene product. This research peptide works as a selective agonist of the KISS1R receptor (GPR54), and it's crucial for neuroendocrine regulation. Here's how it works: Kisspeptin-10 stimulates hypothalamic GnRH neurons, which then influences the hypothalamic-pituitary-gonadal axis in experimental models. Researchers use it to investigate puberty onset mechanisms, reproductive hormone regulation, and metabolic processes. Key preclinical studies have shown just how potent this peptide is at activating KISS1R signalling pathways, with EC50 values in the nanomolar range. Laboratory investigations have looked into its potential for understanding fertility disorders, metabolic syndrome, and circadian rhythm regulation. Our Kisspeptin-10 comes as a sterile, lyophilised white powder with >98% purity that's been verified by HPLC analysis. Each vial contains precisely measured quantities that you can easily reconstitute with sterile water or appropriate buffer solutions. The molecular weight is 1302.4 Da, and we recommend storage at -20°C. This product is exclusively for in vitro research applications in licensed laboratory facilities.

Research Applications

• Investigated for agonist activity at KISS1R / GPR54 receptors in cell-based assays
• Studied for modulation of GnRH neuron firing in hypothalamic-slice preparations
• Researched for influence on LH and FSH release in pituitary-cell models
• Associated with regulation of pubertal-onset signalling in rodent research models
• Investigated for involvement in reproductive-axis and fertility biomarker studies
• Studied for crosstalk with neurokinin B and dynorphin within KNDy-neuron circuits

Research Mechanism — Kisspeptin-10

A simplified summary of what Kisspeptin-10 is studied for in research models. For laboratory in-vitro use only.

1. 1

   Molecular target

   Kisspeptin-10 is investigated as a high-affinity agonist of the kisspeptin receptor. Preclinical work has characterised its role upstream of GnRH neurons.

   • KISS1R / GPR54 (Gαq/11-coupled receptor)
   • Expressed on hypothalamic GnRH neurons
   • Upstream regulator of the HPG axis
2. 2

   Investigated pathways

   Studies have explored phospholipase C activation and intracellular calcium mobilisation following GPR54 engagement. Research has associated the peptide with pulsatile GnRH release in animal models.

   • Gαq/PLCβ/IP3 calcium signalling
   • ERK1/2 MAPK phosphorylation cascade
   • GnRH pulse generator modulation in the arcuate nucleus
3. 3

   Preclinical research applications

   Preclinical studies have explored kisspeptin-10 in rodent reproductive neuroendocrinology models and isolated hypothalamic explants. Not approved for human use.

   • Rodent models of pubertal HPG axis activation
   • Hypothalamic explant LH/FSH release assays
   • GPR54 receptor pharmacology characterisation

For research use only. Kisspeptin-10 is not approved as a medicine in the UK and is not intended for human or veterinary administration. See the compliance page for full terms.