MOTS-c

About MOTS-c

MOTS-c is a 16-amino-acid mitochondrial-derived peptide encoded within the 12S rRNA region of the mitochondrial genome. It has been investigated for its association with AMPK pathway activation, glucose uptake research and metabolic homeostasis in skeletal muscle and adipose tissue models. Supplied as lyophilised powder for in vitro research only.

Research Applications

• Investigated for AMPK pathway activation in skeletal muscle cell-line research
• Studied for glucose-uptake and insulin-sensitivity research in adipocyte cultures
• Researched in mitochondrial-nuclear retrograde signalling pathway studies
• Explored for folate-cycle and one-carbon metabolism modulation research
• Investigated in age-related metabolic decline and exercise-mimetic research models
• Studied for adipose-tissue browning and thermogenic gene-expression research

Research Mechanism — MOTS-c

A simplified summary of what MOTS-c is studied for in research models. For laboratory in-vitro use only.

1. 1

   Molecular target

   A mitochondrial-derived peptide investigated for its activation of cellular energy-sensing kinases and its translocation to the nucleus under metabolic stress in research models.

   • AMP-activated protein kinase (AMPK)
   • Folate-methionine one-carbon cycle enzymes
   • Nuclear stress-response transcription factors
2. 2

   Investigated pathways

   Preclinical studies have explored downstream effects on glucose-uptake signalling, mitochondrial biogenesis markers, and metabolic gene expression in cultured cells.

   • AMPK–ACC metabolic signalling cascade
   • GLUT4 translocation and glucose-uptake assays
   • PGC-1α mitochondrial biogenesis pathway
3. 3

   Preclinical research applications

   Used as a research tool in laboratory models exploring metabolic biology, mitochondrial science, and aging-related cellular research. Not approved for human use.

   • Skeletal muscle insulin-sensitivity models
   • Adipocyte and hepatocyte metabolic assays
   • Age-related mitochondrial dysfunction studies

For research use only. MOTS-c is not approved as a medicine in the UK and is not intended for human or veterinary administration. See the compliance page for full terms.