MOTS-c Pen 40mg

About MOTS-c Pen 40mg

MOTS-c is a 16-amino-acid mitochondrial-derived peptide encoded within the 12S rRNA region of mitochondrial DNA. Research has explored its role in maintaining mitochondrial function under cellular stress, with preclinical models showing modulation of glucose metabolism, fat oxidation, and energy homeostasis. Levels have been observed to rise with exercise, generating interest in MOTS-c as an exercise-mimetic research tool. Supplied as a pre-loaded research pen for in-vitro and preclinical applications.

Research Applications

• Mitochondrial bioenergetics and stress-response research
• Glucose metabolism and insulin-sensitivity studies
• Exercise-mimetic comparative research models
• Energy homeostasis and AMPK pathway investigation
• Ageing and metabolic-health research

Research Mechanism — MOTS-c Pen 40mg

A simplified summary of what MOTS-c Pen 40mg is studied for in research models. For laboratory in-vitro use only.

1. 1

   Molecular target

   A mitochondrial-derived peptide investigated for its activation of cellular energy-sensing kinases and its translocation to the nucleus under metabolic stress in research models.

   • AMP-activated protein kinase (AMPK)
   • Folate-methionine one-carbon cycle enzymes
   • Nuclear stress-response transcription factors
2. 2

   Investigated pathways

   Preclinical studies have explored downstream effects on glucose-uptake signalling, mitochondrial biogenesis markers, and metabolic gene expression in cultured cells.

   • AMPK–ACC metabolic signalling cascade
   • GLUT4 translocation and glucose-uptake assays
   • PGC-1α mitochondrial biogenesis pathway
3. 3

   Preclinical research applications

   Used as a research tool in laboratory models exploring metabolic biology, mitochondrial science, and aging-related cellular research. Not approved for human use.

   • Skeletal muscle insulin-sensitivity models
   • Adipocyte and hepatocyte metabolic assays
   • Age-related mitochondrial dysfunction studies

For research use only. MOTS-c Pen 40mg is not approved as a medicine in the UK and is not intended for human or veterinary administration. See the compliance page for full terms.