NAD+ Pen 500mg

About NAD+ Pen 500mg

Nicotinamide Adenine Dinucleotide (NAD⁺) is a coenzyme found in all living cells with a central role in redox reactions, energy metabolism, and DNA-repair pathways. Cellular NAD⁺ levels have been observed to decline with age in preclinical models, which has driven research interest into its role in longevity and metabolic-health science. Supplied here as a pre-loaded research pen for in-vitro and preclinical-research applications.

Research Applications

• Mitochondrial bioenergetics and ATP-production research models
• DNA-damage response and PARP-pathway studies
• Sirtuin-activation and cellular-ageing research
• Comparative pharmacokinetic studies between NAD⁺ and precursor forms (NMN, NR)
• In-vitro models of metabolic decline and oxidative stress

Research Mechanism — NAD+ Pen 500mg

A simplified summary of what NAD+ Pen 500mg is studied for in research models. For laboratory in-vitro use only.

1. 1

   Molecular target

   NAD+ functions as an obligate cosubstrate for sirtuins, PARPs and CD38, cycling between oxidised (NAD+) and reduced (NADH) states. Cellular NAD+ pools decline with age in preclinical models.

   • SIRT1-7 deacetylase family (NAD+-dependent)
   • PARP1 and PARP2 DNA-damage response enzymes
   • CD38 ectoenzyme and SARM1 axonal NADase
2. 2

   Investigated pathways

   Research examines NAD+ involvement in mitochondrial bioenergetics, redox balance and DNA repair signalling. Precursors such as NMN and NR are studied as biosynthetic inputs.

   • Mitochondrial electron transport and OXPHOS coupling
   • Sirtuin-mediated deacetylation of FOXO and PGC-1a
   • Salvage pathway flux via NAMPT enzymatic activity
3. 3

   Preclinical research applications

   Investigated in rodent and cell-culture models of metabolic decline, mitochondrial dysfunction and senescence-related endpoints. Not approved for human use.

   • Cellular senescence and replicative ageing assays
   • Murine models of metabolic and mitochondrial stress
   • In vitro DNA-damage and oxidative stress endpoints

For research use only. NAD+ Pen 500mg is not approved as a medicine in the UK and is not intended for human or veterinary administration. See the compliance page for full terms.