Selank

About Selank

Selank is a synthetic heptapeptide that's built from tuftsin, an immunomodulatory tetrapeptide. The clever bit? Researchers added a Pro-Gly-Pro extension that makes it much more stable against enzyme breakdown - perfect for extended lab studies. This nootropic peptide has caught scientists' attention because of how it works with GABAergic neurotransmitter systems and regulates enkephalin expression. Lab studies show Selank affects cytokine balance, especially in neuroinflammatory models. Its interaction with GABA receptors points to interesting possibilities for anxiety and cognitive research. Recent work has looked at its neuroprotective properties and how it can influence stress response pathways in both cellular and animal models. We supply it as pharmaceutical-grade lyophilised powder with >98% purity verification. Each vial contains precisely measured quantities that work well for controlled in vitro studies. You'll need to store it at -20°C with desiccant protection. Molecular weight: 751.9 g/mol. Sequence: Thr-Lys-Pro-Arg-Pro-Gly-Pro. This is exclusively for laboratory research applications - it's not for human consumption or therapeutic use.

Research Applications

• Investigated for anxiolytic-like activity in rodent behavioural models
• Studied for modulation of GABAergic signalling and BDNF expression in vitro
• Researched for influence on enkephalin and serotonin metabolism in CNS tissue
• Associated with cytokine and interferon balance in neuroimmune research models
• Investigated as a stable analogue of tuftsin for receptor-binding studies
• Studied for effects on stress-response biomarkers in preclinical research

Research Mechanism — Selank

A simplified summary of what Selank is studied for in research models. For laboratory in-vitro use only.

1. 1

   Molecular target

   Selank is investigated as an indirect modulator of GABAergic neurotransmission, without direct high-affinity binding at a single canonical receptor. Tuftsin-like immunomodulatory activity is also studied.

   • GABA-A receptor system — indirect modulation
   • Enkephalin / endogenous opioid pathway interaction
   • Tuftsin-receptor immunomodulatory signalling
2. 2

   Investigated pathways

   Research examines effects on monoamine turnover, BDNF expression and enkephalinase inhibition in rodent CNS tissue. Cytokine balance is a secondary research endpoint.

   • BDNF and NGF neurotrophin expression in hippocampus
   • Serotonin and dopamine turnover in limbic regions
   • Th1 / Th2 cytokine balance in immunological assays
3. 3

   Preclinical research applications

   Investigated in rodent models of anxiety-like behaviour, stress reactivity and learning paradigms. Not approved for human use.

   • Elevated plus maze and open field anxiety assays
   • Passive avoidance and Morris water maze learning
   • Restraint-stress and corticosterone rodent models

For research use only. Selank is not approved as a medicine in the UK and is not intended for human or veterinary administration. See the compliance page for full terms.