Thymosin Alpha-1 research peptide
Immunity

Thymosin Alpha-1

28-amino-acid N-acetylated thymic peptide (Tα1) researched for innate and adaptive immune signalling.

Purity

99%+

CAS Number

62304-98-7

Status

Made to Order

Dispatch

Same-Day (before 2pm)

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£199.99

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Research verification required. All orders are reviewed before dispatch. You will receive an email confirmation and a WhatsApp or phone call within 60 minutes to verify your research purpose.

Third-Party CoA Included Free Delivery Over £75 Research Use Only

About Thymosin Alpha-1

Thymosin Alpha-1 (Tα1) is a 28-amino-acid N-acetylated peptide originally isolated from thymic fraction 5 and derived from the prothymosin alpha precursor. It has been investigated extensively for its association with TLR signalling, T-cell maturation research and innate-immune modulation. Supplied as lyophilised powder for in vitro research only.

Research Applications

Research Mechanism — Thymosin Alpha-1

A simplified summary of what Thymosin Alpha-1 is studied for in research models. For laboratory in-vitro use only.

Sequence:Ac-SDAAVDTSSEITTKDLKEKKEVVEEAEN (28 aa, N-terminal acetylated)

Origin: N-terminally acetylated 28-amino-acid peptide originally isolated from thymic tissue (Thymosin Fraction 5) and now produced by solid-phase synthesis.

  1. Molecular target

    Tα1 has been investigated as a ligand at innate immune pattern-recognition receptors expressed on antigen-presenting cells. Engagement is reported to influence dendritic cell maturation.

    • Studied agonism at TLR2 and TLR9 receptors
    • Investigated effects on dendritic cell maturation markers
    • Probed modulation of MyD88 adaptor signalling

  2. Investigated pathways

    Preclinical literature characterises downstream cytokine and T-cell polarisation responses. Effects on transcription factor activation have also been examined.

    • NF-κB and IRF transcription factor activation
    • Th1 cytokine output including IFN-γ and IL-2
    • CD4+/CD8+ T-cell and NK cell population dynamics

  3. Preclinical research applications

    Used in laboratory models of viral challenge, immunosuppression, and vaccine adjuvant research. Not approved for human use.

    • Murine viral infection immune response models
    • Cyclophosphamide-induced immunosuppression studies
    • In vitro PBMC cytokine release and proliferation assays

For research use only. Thymosin Alpha-1 is not approved as a medicine in the UK and is not intended for human or veterinary administration. See the compliance page for full terms.

Technical Specifications

Compound NameThymosin Alpha-1
CategoryImmunity
CAS Number62304-98-7
Molecular Weight3108.32 g/mol
Molecular FormulaC₁₂₉H₂₁₅N₃₃O₅₅
SequenceAc-SDAAVDTSSEITTKDLKEKKEVVEEAEN (28-aa N-acetylated peptide)
Purity≥99%+ (HPLC)
FormLyophilised powder
StorageStore lyophilised at -20°C. Protect from light. Reconstituted: aliquot and store at -80°C. Use within 30 days of reconstitution.
ReconstitutionReconstitute in bacteriostatic or sterile water. Typical stock concentration: 1 mg/mL.

Certificate of Analysis

Every order of Thymosin Alpha-1 includes a batch-specific CoA with HPLC chromatogram, mass spectrometry data, and laboratory accreditation details.

View Sample CoA

Thymosin Alpha-1 — Frequently Asked Questions

What is Thymosin Alpha-1?

Thymosin Alpha-1 (Tα1) is a 28-amino-acid N-acetylated thymic peptide studied in laboratory research for its association with TLR signalling, T-cell maturation and innate-immune modulation. It is supplied for in vitro research only.

What purity is your Thymosin Alpha-1?

99%+, confirmed by independent third-party HPLC analysis. Batch-specific CoA included.

Is Thymosin Alpha-1 approved for human use?

No. Supplied for in vitro laboratory research only. Not a licensed medicine.

📊Certificates of Analysis🔬Quality & Testing📋Research Guidelines⚖️UK Compliance

Thymosin Alpha-1 is supplied by Premio Peptides (BELL RED LIMITED) exclusively for in vitro laboratory research. It is not a licensed medicine, is not approved for human or veterinary use, and must not be administered to any living organism outside a formally approved research protocol. Purchasers assume full responsibility for compliance with applicable regulations.

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